TLDR: It's not sure, don't use your cheated save online. However I describe some ways that should be less likely to lead to bans.
Theoretically if you use any cheat that only applies to the running game, such as infinite item usage & inf health should not lead to problems.
So you could save your best Golden Rune and get inf runes while runeMemory stays consistent.
Or you could get inf damage & inf health and just kill everything for runes.
HOWEVER: This is based on past games, and while eac is disabled we do not know about the consistency checks in the game.
If you want to try it out it's on your head.
I think everybody here would be thankful if you gave us more info, but you need to say if potentially being banned is worth it.
The safest option might be once we figure out on which day the bans happen to buy it on a burner account before, then do the cheat, see once the checks happened if you are banned, and refund if you are.
Generally do not test things that resulted in bans in past games, it's safe to assume that those will also lead to bans.
And like I said before, theoretically anything that doesn't directly modify a value that is saved should be safe (so anything that merely empowers/makes easy legit acquisition) but no guarantees if it actually is.
How to use this cheat table?
- Install Cheat Engine
- Double-click the .CT file in order to open it.
- Click the PC icon in Cheat Engine in order to select the game process.
- Keep the list.
- Activate the trainer options by checking boxes or setting values from 0 to 1